AlphaGenome 2
Google DeepMind released AlphaGenome 2, a DNA model that predicts how genetic variants change gene activity in specific human cell types and states, trained on over 107 million cell profiles.
The first AlphaGenome gave fixed parallel outputs for bulk tissues and cell lines. AlphaGenome 2 takes a tissue, cell type or cell state as an input next to the DNA sequence and predicts one condition at a time. It adds DNA methylation to the earlier readouts, and a cell encoder lets scientists build a condition from their own single-cell data without retraining.
- Date
- Wednesday 11 November 2026
- Lab
- Google DeepMind
- Kind
- model
- Access
- closed API
Figures
| Measure | Value | Measured by |
|---|---|---|
| Causal variants identified on TenK10K (28 immune cell types) | 30% vs 16% for best comparison model compared with the original AlphaGenome fine-tuned on single-cell data and other specialised tools | company |
| Correct direction of gene effect on TenK10K | 43% vs 23% best comparison model | company |
| Training data | over 107 million individual cell profiles, 68 tissues human and mouse bulk and single-cell data | company |
Available through the AlphaGenome API for non-commercial research, commercial research is in private preview, and it is not validated for clinical use. Weights are not mentioned. It costs more compute than the original, which stays in service.
Sources
- deepmind.google/blog/alphagenome-2-deciphering-how-cells-read-dna-to-better-understand-dis
- mlq.ai/news/google-deepmind-releases-alphagenome-2-to-predict-how-dna-changes-affect-speci
- theverge.com/ai-artificial-intelligence/1031524/google-deepmind-alphagenome-2-genetic-ai-m
- dataconomy.com/2026/11/12/google-deepmind-releases-alphagenome-2-to-study-disease/
- digitaltoday.co.kr/en/view/124629/google-deepmind-unveils-alphagenome-2-ai-to-pinpoint-cau
- yourstory.com/ai-story/google-deepmind-unveils-alphagenome-2-to-study-dna-changes
This record was partly confirmed: some claims could not be checked on 11 November 2026. How we check